I present here a personal perspective on more than three decades of research into the structural biology of the insulin–receptor interaction. The solution of the three‐dimensional structure of insulin in 1969 provided a detailed understanding of the insulin surfaces involved in self‐assembly. In subsequent years, hundreds of insulin analogues were prepared by insulin chemists and molecular biologists, with the goal of relating the structure to the biological function of the molecule. The design of methods for direct receptor‐binding studies in the (...) 1970s, and the cloning of the receptor in the mid 1980s, provided the required tools for detailed structure–function studies. In the absence of a full three‐dimensional structure of the insulin–receptor complex, I attempt to assemble the existing pieces of the puzzle generated by our and other laboratories, in order to generate a plausible mechanistic model of the insulin–receptor interaction that explains its kinetics and negative cooperativity. BioEssays 26:1351–1362, 2004. © 2004 Wiley Periodicals, Inc. (shrink)

Progress in solving the structure of insulin bound to its receptor has been slow and stepwise, but a milestone has now been reached with a refined structure of a complex of insulin with a “microreceptor” that contains the primary binding site. The insulin receptor is a dimeric allosteric enzyme that belongs to the family of receptor tyrosine kinases. The insulin binding process is complex and exhibits negative cooperativity. Biochemical evidence suggested that insulin, through two distinct binding sites, crosslinks two receptor (...) sites located on each α subunit. The structure of the unliganded receptor ectodomain showed a symmetrical folded‐over conformation with an antiparallel disposition. Further work resolved the detailed structure of receptor site 1, both without and with insulin. Recently, a missing piece in the puzzle was added: the C‐terminal portion of insulin's B‐chain known to be critical for binding and negative cooperativity. Here I discuss these findings and their implications. (shrink)

This article presents a relatively straightforward theoretical framework about distributive justice with applications. It draws on a few key concepts of Sociological Game Theory. SGT is presented briefly in section 2. Section 3 provides a spectrum of distributive cases concerning principles of equality, differentiation among recipients according to performance or contribution, status or authority, or need. Two general types of social organization of distributive judgment are distinguished and judgment procedures or algorithms are modeled in each type of social organization. Section (...) 4 discusses briefly the larger moral landscapes of human judgment – how distribution may typically be combined with other value into consideration. The article suggests that Rawls, Elster, and Machado point in this direction. Finally, it is suggested that the SGT framework presented provides a useful point of departure to systematically link it and compare the Warsaw School of Fair Division, Rawls, and Elster, among others. (shrink)

How Tocqueville’s ideas can help us build resilient liberal democracies in a divided world How can today’s liberal democracies withstand the illiberal wave sweeping the globe? What can revive our waning faith in constitutional democracy? Tocqueville’s Dilemmas, and Ours argues that Alexis de Tocqueville, one of democracy’s greatest champions and most incisive critics, can guide us forward. Drawing on Tocqueville’s major works and lesser-known policy writings, Ewa Atanassow shines a bright light on the foundations of liberal democracy. She argues that (...) its prospects depend on how we tackle three dilemmas that were as urgent in Tocqueville’s day as they are in ours: how to institutionalize popular sovereignty, how to define nationhood, and how to grasp the possibility and limits of global governance. These are pivotal but often neglected dimensions of Tocqueville’s work, and this fresh look at his writings provides a powerful framework for addressing the tensions between liberalism and democracy in the twenty-first century. Recovering a richer liberalism capable of weathering today’s political storms, Tocqueville’s Dilemmas, and Ours explains how we can reclaim nationalism as a liberal force and reimagine sovereignty in a global age—and do so with one of democracy’s most discerning thinkers as our guide. (shrink)

Le but de cet article consiste à présenter des influences de l’évolutionnisme Darwinien et des idées de Frederick Matthias Alexander sur l’esthétique naturaliste de John Dewey. Ces influences menaient Dewey à sa propre version de l’esthétique naturaliste, c’est-à-dire une conception large, non cartésienne, dynamique d’un sujet, qui peut aussi inclure des animaux. Par conséquent John Dewey construisait une sorte d’anti-anthropocentrisme, ce qui décidait que son esthétique était en avance sur son temps.

L'intention de ce texte est de présenter l'opinion de Leszek Kołakowski sur la relations entre le discours de la rationalité et celui de la foi. Chacun de ces domaines a son propre discours qui lui est specifique et intraduisible. En general, la réflexion de Kołakowski tand à prouver que la présence d'un Absolu est necessaire. Ici, cet Absolu a le visage de Dieu. C'est Lui qui permet de reconnaître comme valables les principes moraux qui en dehors de la foi sont (...) dépourvus de fondement. Ces principes ont évolué à partir du discours de la foi et ont été adaptés à l'ordre de la vie quotidienne. (shrink)

Muslims are a marginal minority in Poland, but research shows that they are often subject to negative perceptions and hostility from the majority. Orientalist stereotypes about Islam and the people associated with it are widespread and often reproduced in the media. Research from North America and the European Court of Human Rights suggests that such prejudices can affect the adjudication of cases involving Muslims. It may be presumed that Poland is no exception to that, and this assumption was the starting (...) point for our empirical study. To date, there have been no studies on the perception of Muslims and Islam in the Polish legal system. This article presents the results of a qualitative thematic analysis of 57 judicial opinions issued by the common courts in Poland and published online, in which Islam or being Muslim was mentioned. The cases were categorised and texts of the judicial opinions closely analysed (with computer-assisted qualitative data analysis software) to identify recurring themes. The findings of this first exploratory study show that stereotypical representations and the “‘Othering” of Muslims do indeed occur in Polish courts, with some judges repeating Orientalist tropes that have become normalised in Polish society. (shrink)

The article analyses the royal proclamation of Ferdinand VI in Cusco which took place on 23 September 1747, on the birthday of the king. A reconstruction of the celebration was possible thanks to two sources: the city chronicle written in the mid-eighteenth century by Diego de Esquivel y Navía and an occasional print containing a description of the ceremony by José Antonio Santander. The article discusses three aspects of the presented celebrations. First of all, it presents the general context, i.e. (...) the problem of festival celebrations related to the royal family as a part of the Spanish crown policy. Secondly, it details artistic issues related to the celebrations. It includes a description of the artistic setting with the features of occasional architecture and ephemeral painting. Finally, the article examines the local, social and political contexts of the celebrations, read as a manifestation of the city’s emancipation efforts based on the emphasis of Cusco’s antiquity and its rich imperial tradition in the Pre-Hispanic period. (shrink)

As it has been shown by Kazuo Ishiguro in his novel The Buried Giant (2015), the dragon can perform functions that contradict the reader’s expectations. The female dragon Querig has a paradoxal character—passive and withdrawn, it influences other characters and its environment in various ways, contrary to other similar creatures portrayed in fantasy literature, with which this specific figure is mainly associated. Querig’s double nature allows the author to explore the subjects of memory and trauma, both symbolized by the dragon.

Dans cet article, les auteurs présentent une séance en thérapie de couple riche en matériel psychique inconscient. Se référant à la théorie psychanalytique groupale et familiale, elles montrent que la cothérapie, loin d’être un dispositif défensif, peut se concevoir comme la création d’une enveloppe psychique, chrysalide qui contribue à l’accès à l’altérité et à l’individuation pour des couples fondés sur une collusion narcissique où prédomine l’angoisse d’abandon.

The purpose of this article is to reflect on selected works of Aleksander Watt placed in the context of De imitatione Christi by Thomas à Kempis and to verify the view that suffering functions in the consciousness and poetic imagination of the writer as a value conducive to the spiritual development of the individual. The author analyzes the poet’s memoirs in order to show how reading the book he discovered during WWII, while exiled in Kazakhstan, influenced Wat’s choices and attitudes, (...) or his perception of the decisions he made. Then the article interprets the poetic texts that emphasize the theme of suffering and following Jesus Christ. The Wiersze somatyczne [Somatic Poems] cycle is discussed, on top of Wat’s works based on the symbolism of the crown of thorns and the death on the cross, the excerpts from his drama Kobiety z Monte Olivetto [The Women of Monte Olivetto], and the poem with the incipit “U szczytu antynomij….” [At the top of antinomies...], which is formed into the shape of the cross. The researcher reads them in a hermeneutical way in the course of which she analyzes the symbols and biblical allusions, associates literary metaphors with autobiographical traces of the poet’s experiences, and uncovers the connection between the texts of the two authors. The main thesis of the article is that in the discussed works, there is a dolorous theme – that is, one in which suffering is exposed and presented as an ethically valuable experience. A reading of a number of works in which pain, depicted in various ways, is at the same time a reminiscence of the poet’s own physical and mental anguish and a reference to the Passion of Christ, allows one to conclude that for the author of Wiersze śródziemnomorskie [The Mediterranean Poems], suffering is a state of spiritual transformation that brings man closer to the sphere of the sacred. The author ultimately concludes that, in light of the work of Thomas à Kempis, Wat’s dolorism appears as a modern interpretation of the idea of following Christ, marked by the necessity of being different from Him. (shrink)

There are two interrelated questions that I would like to explore in the context of Pleshette DeArmitt’s work. The first one pertains to the intellectual stakes in the eloquent style of her writing, its elegance and playfulness, which accompanies the philosophical order of argumentation. And the second one refers to the issue of female friendship. How can one discuss such friendship without resorting to merely biographical, historical, or autobiographical terms? Yet what kind of philosophical theories of female friendship could I (...) possibly refer to? Perhaps to none. DeArmitt, whose life has created so many friendships, did not live long enough to write about friendship, at least not directly. And yet I would like to suggest that her captivating—the adjective that I use here deliberately—book, The Right to Narcissism: A Case for Im-possible Self-Love, leaves us traces of female friendship in her philosophical argument that narcissistic self-love is inseparable from the love of another. (shrink)

This collection of essays uses Alexis de Tocqueville's writings as a jumping-off point to explore the dilemmas of democratization in the twenty-first century.

The SARS-CoV-2 pandemic has transgressed biomedical categories. According to Horton, it turned out to be a 'syndrome' that infected virtually all spheres of social life. The pandemic has created toxic social atmosphere highly unfavorable to clinical and clinic-ethical decision making. Constraints and pressures related to micro-, meso-, exo- and macro-environments framing doctors, nurses, and medical students in training were identified. These factors exacerbated moral distress (moral injury) amongst clinicians. In a joint Polish-Lithuanian project (IDUB 2020-2022) we examined predictors of moral (...) distress in pandemic clinical contexts. A survey-based, real-time, correlational and comparative study was conducted in Poland and Lithuania after the first year of pandemic with N=227 participants. Unexpected differences on regular and pandemic-type moral distress levels were found between the two national samples. Polish participants showed significantly higher moral distress levels than their Lithuanian counterparts. The following article discusses these findings and recommends the reinforcement of resilient medical decision making. (shrink)

Liberalism has been one of the leading incarnations of political thought for the past two centuries and it was also the first form of political theory to acquire a truly global reach. This volume examines the work of the most pivotal thinkers in the liberal tradition, starting with Montesquieu and proceeding to a wide range of authors from the French Revolution to the present. The book is distinctive in encompassing the wide spectrum of views historically encompassed by liberalism, revealing its (...) geographical as well as intellectual scope by including conceptions of liberalism formed in Latin America, the Middle East and Asia. Twenty-four chapters cover thinkers including Madame de Stael, Alexis de Tocqueville, Abraham Lincoln, John Stuart Mill Ahmad Faris al-Shidyaq, John Dewey, Hu Shih, Hannah Arendt and John Rawls. Each chapter offers a commentary on a short critical passage from the author concerned. Essayists use their chosen passage to explore the meaning and significance of the author's work for both the historical tradition of liberalism and for political thought more generally. The book is organized chronologically, building up a richly detailed overview of the tradition of liberalism and its key writings. The book will be an indispensible companion to courses on liberal thought, on political ideologies and on the history of political thought and will be of interest to students and scholars of politics, philosophy and history. (shrink)

One of two primary aims of this article is to advance a pragma-cognitive approach to the analysis of narrative reports used as parts of short narratives which draws on two salient theories: the Cognitive Approach proposed by Chilton (2004, 2005, 2010, 2014) and Cap's (2006, 2010, 2013, 2017) Proximisation Theory. The other equally important objective is to propose a taxonomy of covert sayers, i.e. actors whose words are reported by the current speaker (cf. Vandelanotte 2006, 2008, 2009), whose identity is (...) concealed and may be retrieved via inferences drawn on the basis of shared values and common ground. This paper essentially concentrates on sayer's utterances rendered via reported speech frames and explains their role in maintaining the aura of belonging and inclusion, as well as of dissociation and exclusion. My research assumes that reported speech frames are selected strategically as rhetorical devices to foster (de)legitimisation and image construction. The research data comprises a corpus of texts of presidential public addresses written to be delivered rather than transcripts of spoken discourse, as its purpose is to investigate the process of speech construction. (shrink)

Im Folgenden soll der Entwicklung des Begriffs der Anerkennung in der klassischen deutschen Philosophie nachgegangen werden. Dabei sind zwei Thesen zu formulieren: Erstens, fand der Gedanke der Anerkennung nicht erst bei Fichte und Hegel seinen Ausdruck, sondern wurde schon früher im Rahmen der Spätphilosophie Immanuel Kants entwickelt. Zweitens, zeigt sich zwischen diesen drei Auslegungen eine erstaunliche Kontinuität. Der Frage, worin diese näher besteht, möchte ich mich im Besonderen zuwenden.

Im Folgenden soll der Entwicklung des Begriffs der Anerkennung in der klassischen deutschen Philosophie nachgegangen werden. Dabei sind zwei Thesen zu formulieren: Erstens, fand der Gedanke der Anerkennung nicht erst bei Fichte und Hegel seinen Ausdruck, sondern wurde schon früher im Rahmen der Spätphilosophie Immanuel Kants entwickelt. Zweitens, zeigt sich zwischen diesen drei Auslegungen eine erstaunliche Kontinuität. Der Frage, worin diese näher besteht, möchte ich mich im Besonderen zuwenden.

What kind of challenge does sexual and racial difference pose for postmodern ethics? What is the relation between ethical obligation and feminist interpretations of embodiment, passion, and eros? How can we negotiate between ethical responsibility for the Other and democratic struggles against domination, injustice, and equality, on the one hand, and internal conflicts within the subject, on the other? We cannot address such questions, Ziarek argues, without putting into dialogue discourses that have hitherto been segregated: postmodern ethics, feminism, race theory, (...) and the idea of radical democracy. Addressing a constellation of diverse thinkers - including Emmanuel Levinas, Patricia Williams, Jean-François Lyotard, Michel Foucault, Frantz Fanon, Julia Kristeva, and Luce Irigaray - the author proposes a new conception of ethics, an ethics of dissensus that rethinks the relation between freedom and obligation in a double context of embodiment and antagonism. (shrink)

Experimental emotion inductions provide the strongest causal evidence of the effects of emotions on psychological and physiological outcomes. In the present qualitative review, we evaluated five common experimental emotion induction techniques: visual stimuli, music, autobiographical recall, situational procedures, and imagery. For each technique, we discuss the extent to which they induce six basic emotions: anger, disgust, surprise, happiness, fear, and sadness. For each emotion, we discuss the relative influences of the induction methods on subjective emotional experience and physiological responses. Based (...) on the literature reviewed, we make emotion-specific recommendations for induction methods to use in experiments. (shrink)

Ewa Ziarek fully articulates a feminist aesthetics, focusing on the struggle for freedom in women's literary and political modernism and the devastating impact of racist violence and sexism. She examines the contradiction between women's transformative literary and political practices and the oppressive realities of racist violence and sexism, and she situates these tensions within the entrenched opposition between revolt and melancholia in studies of modernity and within the friction between material injuries and experimental aesthetic forms. Ziarek's political and aesthetic investigations (...) concern the exclusion and destruction of women in politics and literary production and the transformation of this oppression into the inaugural possibilities of writing and action. Her study is one of the first to combine an in-depth engagement with philosophical aesthetics, especially the work of Theodor W. Adorno, with women's literary modernism, particularly the writing of Virginia Woolf and Nella Larsen, along with feminist theories on the politics of race and gender. By bringing seemingly apolitical, gender-neutral debates about modernism's experimental forms together with an analysis of violence and destroyed materialities, Ziarek challenges both the anti-aesthetic subordination of modern literature to its political uses and the appreciation of art's emancipatory potential at the expense of feminist and anti-racist political struggles. (shrink)

The study aims to analyse the clinical proceedings in pregnant women diagnosed with brain death. Apart from the diagnostic premises and the patient’s rights, the ontological status of the foetus proves to be a severe problem. In reference to the principles of zeroth-order logic, the assumption of potential used by personalists is not a tautology.

Cognitive Linguistics is an approach to language study based on three central premises: that the function of language is to convey meaning, that linguistic description must rely on constructs that are psychologically real, and that grammar emerges from usage. Over the last 40 years, this approach to studying language has made enormous strides in virtually every aspect of linguistic inquiry, achieving major insights as well as bringing about a conceptual unification of the language sciences. However, it has also faced problems, (...) which, I argue, must be addressed if the approach is to continue to flourish. Some of these are shared with generative linguistics, while some are peculiar to the cognitive approach. The former include excessive reliance on introspective evidence; paying only lip service to the Cognitive Commitment; too much focus on hypothesis formulation (and not enough on hypothesis testing); ignoring individual differences; and neglecting the social aspects of language. The latter include assuming that we can deduce mental representations from patterns of use and equating distribution with meaning. I conclude by sketching out how these pitfalls could be avoided. (shrink)

Name der Zeitschrift: Cognitive Linguistics Jahrgang: 27 Heft: 4 Seiten: 479-491.

Changes in Metaphor Comprehension in Children The aim of the study was to follow the implicit patterns in children's responses to metaphor describing human by means of a name of animal. The main problem in present study was: which traits of topic would be spontaneously used by children from three age groups? The study followed a quasi-experimental design. The subjects were 77 children from three age groups: 5;6-6;0, 8;0-8;6, 9;6-10;0. The dependent variable: the level of comprehension of 18 metaphors with (...) vehicles from the animal domain and one topic - human. The variable was measured through individual Piagetian interviews. The study confirmed the hypothesis that the ability to activate metaphorical thinking in order to describe human attributes increases with age, with a turning point around 8 year of life. The traits mentioned by subjects could be classified into five categories: unambiguous evaluations, physical features, behavior, behavioral traits, dispositions and agency. Older children assigned more human dispositional traits, thoughts and preferences to the objects of metaphors. Younger ones often focused on the physical features of animals. With age, the tendency to give positive evaluations to the objects of metaphors increases. (shrink)

This paper examines early syntactic development from a usage-based perspective, using transcripts of the spontaneous speech of two Englishspeaking children recorded at relatively dense intervals at ages 2;0 and 3;0. We focus primarily on the children’s question constructions, in an effort to determine (i) what kinds of units they initially extract from the input (their size and degree of specificity / abstractness); (ii) what operations they must perform in order to construct novel utterances using these units; and (iii) how the (...) units and the operations change between the ages of two and three. In contrast to nativist theories of language development which suggest that children are working with abstract syntactic categories from an early point in development, we suggest that the data are better accounted for by the proposal that children begin with lexically specific phrases and gradually build up a repertoire of increasingly abstract constructions. (shrink)